Genetic Identification of Two Novel Loci Associated with Steroid-Sensitive Nephrotic Syndrome.

ABSTRACT:

Background

Steroid-sensitive nephrotic syndrome (SSNS), the most common form of nephrotic syndrome in childhood, is considered an autoimmune disease with an established classic HLA association. However, the precise etiology of the disease is unclear. In other autoimmune diseases, the identification of loci outside the classic HLA region by genome-wide association studies (GWAS) has provided critical insights into disease pathogenesis. Previously conducted GWAS of SSNS have not identified non-HLA loci achieving genome-wide significance.

Methods

In an attempt to identify additional loci associated with SSNS, we conducted a GWAS of a large cohort of European ancestry comprising 422 ethnically homogeneous pediatric patients and 5642 ethnically matched controls.

Results

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SUBMITTER: Dufek S 

PROVIDER: S-EPMC6683715 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature