A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt⁺Foxp3⁺ Tregs with Enhanced Suppressive Capacity.

ABSTRACT:

Background

New therapies blocking the IL-6 receptor (IL-6R) have recently become available and are successfully being used to treat inflammatory diseases like arthritis. Whether IL-6 blockers may help patients with kidney inflammation currently remains unknown.

Methods

To learn more about the complex role of CD4⁺ T cell-intrinsic IL-6R signaling, we induced nephrotoxic nephritis, a mouse model for crescentic GN, in mice lacking T cell-specific IL-6Ra. We used adoptive transfer experiments and studies in reporter mice to analyze immune responses and Treg subpopulations.

Results

Lack of IL-6Ra signaling in mouse CD4⁺ T cells impaired the generation of proinflammatory Th17 cells, but surprisingly did not ameliorate the course of GN. In contrast, ren

SUBMITTER: Hagenstein J 

PROVIDER: S-EPMC6683717 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature