2,3,7,8-Tetrachlorodibenzo-p-dioxin modifies alternative splicing in mouse liver.

ABSTRACT: Alternative splicing is a co-transcriptional mechanism that generates protein diversity by including or excluding exons in different combinations, thereby expanding the diversity of protein isoforms of a single gene. Abnormalities in this process can result in deleterious effects to human health, and several xenobiotics are known to interfere with splicing regulation through multiple mechanisms. These changes could lead to human diseases such as cancer, neurological disorders, autoimmune diseases, and developmental disorders. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant generated as a byproduct of various industrial activities. Exposure to this dioxin has been linked to a wide range of pathologies through the alteration of multiple cellular processes. However,

SUBMITTER: Villasenor-Altamirano AB 

PROVIDER: S-EPMC6684058 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature