The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy.

ABSTRACT: The initial interaction between a microbial pathogen and the host immune response influences the outcome of the battle between the host and the foreign invader. Leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, provides a model to study relevant human immune responses. Previous studies have adopted a targeted approach to investigate host response to M. leprae infection, focusing on the induction of specific molecules and pathways. By measuring the host transcriptome triggered by M. leprae infection of human macrophages, we were able to detect a host gene signature 24-48 hours after infection characterized by specific innate immune pathways involving the cell fate mechanisms autophagy and apoptosis. The top upstream regulator in the M. leprae-induced gene signatur

SUBMITTER: R Andrade P 

PROVIDER: S-EPMC6684084 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature