Shift models for dose-finding in partially ordered groups.

ABSTRACT:

Background

Limited options are available for dose-finding clinical trials requiring group-specific dose selection. While conducting parallel trials for groups is an accessible approach to group-specific dose selection, this approach allows for maximum tolerated dose selection that does not align with clinically meaningful group order information.

Methods

The two-stage continual reassessment method is developed for dose-finding in studies involving three or more groups where group frailty order is known between some but not all groups, creating a partial order. This is an extension of the existing continual reassessment method shift model for two ordered groups. This method allows for dose selection by group, where maximum tolerated dose selection follows the known frailty or

SUBMITTER: Horton BJ 

PROVIDER: S-EPMC6684162 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature