Ontology highlight
ABSTRACT:
SUBMITTER: Zhu SJ
PROVIDER: S-EPMC6684230 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
eLife 20190712
Individual malaria infections can carry multiple strains of <i>Plasmodium falciparum</i> with varying levels of relatedness. Yet, how local epidemiology affects the properties of such mixed infections remains unclear. Here, we develop an enhanced method for strain deconvolution from genome sequencing data, which estimates the number of strains, their proportions, identity-by-descent (IBD) profiles and individual haplotypes. Applying it to the Pf3k data set, we find that the rate of mixed infecti ...[more]