Limbic and prefrontal neural volume modulate social anxiety in children at temperamental risk.

ABSTRACT:

Background

Clinical levels of a social anxiety disorder (SAD) often appear during childhood and rise to a peak during late adolescence. The temperament trait behavioral inhibition (BI), evident early in childhood, has been linked to increased risk for SAD. Functional and structural variations in brain regions associated with the identification of, and response to, fear may support the BI-SAD relation. Whereas relevant functional studies are emerging, the few extant structural studies have focused on adult samples with mixed findings.

Methods

A moderated-mediation model was used to examine the relations between BI, SAD symptoms, and brain-volume individual differences in a sample of children at risk for anxiety (ages 9-12; N = 130, 52 BI).

Results

Our findings indicate

SUBMITTER: Auday ES 

PROVIDER: S-EPMC6684311 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature