Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass: Randomized Controlled Trial.

ABSTRACT:

Background

The efficacy of intraoperative corticosteroids to improve outcomes following congenital cardiac operations remains controversial.

Objectives

The purpose of this study was to determine whether intraoperative methylprednisolone improves post-operative recovery in neonates undergoing cardiac surgery.

Methods

Neonates undergoing cardiac surgery with cardiopulmonary bypass at 2 centers were enrolled in a double-blind randomized controlled trial of methylprednisolone (30 mg/kg) or placebo after the induction of anesthesia. The primary outcome was a previously validated morbidity-mortality composite that included any of the following events following surgery before discharge: death, mechanical circulatory support, cardiac arrest, hepatic injury, renal injury, or r

SUBMITTER: Graham EM 

PROVIDER: S-EPMC6684326 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature