Brain Aging in Midlife: The Beaver Dam Offspring Study.

ABSTRACT:

Objectives

Middle age has been identified as a critical time period for health later in life. Identifying factors associated with worse brain function in middle-aged adults may help identify ways to preserve brain function with aging. Our objective was to evaluate factors associated with a novel measure of brain aging in middle-aged and older adults.

Design

Longitudinal cohort study.

Setting

Beaver Dam Offspring Study (BOSS) baseline (2005-2008), 5-year (2010-2013), and 10-year examinations (2015-2017).

Participants

A total of 2285 adults, 22 to 84 years of age, with complete sensorineural and neurocognitive data at the 5-year examination.

Measurements

Principal component analysis (PCA) was performed combining 5-year sensorineural (hearing, vision, olfac

SUBMITTER: Schubert CR 

PROVIDER: S-EPMC6684355 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature