IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.

ABSTRACT: Th17 cells play a critical role in the adaptive immune response against extracellular bacteria, and the possible mechanisms by which they can protect against infection are of particular interest. In this study, we describe, to our knowledge, a novel IL-1β dependent pathway for secretion of the antimicrobial peptide IL-26 from human Th17 cells that is independent of and more rapid than classical TCR activation. We find that IL-26 is secreted 3 hours after treating PBMCs with Mycobacterium leprae as compared with 48 hours for IFN-γ and IL-17A. IL-1β was required for microbial ligand induction of IL-26 and was sufficient to stimulate IL-26 release from Th17 cells. Only IL-1RI⁺ Th17 cells responded to IL-1β, inducing an NF-κB-regulated transcriptome. Finally, supernatants fro

SUBMITTER: Weiss DI 

PROVIDER: S-EPMC6684376 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature