Tau positron emission tomography imaging in C9orf72 repeat expansion carriers.

ABSTRACT:

Background and purpose

AV-1451 (¹⁸ F-AV-1451, flortaucipir) positron emission tomography was performed in C9orf72 expansion carriers to assess tau accumulation and disease manifestation.

Methods

Nine clinically characterized C9orf72 expansion carriers and 18 age- and gender- matched cognitively normal individuals were psychometrically evaluated and underwent tau positron emission tomography imaging. The regional AV-1451 standard uptake value ratios from multiple brain regions were analyzed. Spearman correlation was performed to relate the AV-1451 standard uptake value ratio to clinical, psychometric and cerebrospinal fluid measures.

Results

C9orf72 expansion carriers had increased AV-1451 binding in the entorhinal cortex compared to controls. Primary age-re

SUBMITTER: Ly CV 

PROVIDER: S-EPMC6684398 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature