Gluten Intake and Risk of Celiac Disease: Long-Term Follow-up of an At-Risk Birth Cohort.

ABSTRACT:

Objectives

To determine the association between the amount of gluten intake in childhood and later celiac disease (CD), for which data are currently scarce.

Methods

The prospective Diabetes Autoimmunity Study in the Young cohort includes 1875 at-risk children with annual estimates of gluten intake (grams/d) from age 1 year. From 1993 through January 2017, 161 children, using repeated tissue transglutaminase (tTGA) screening, were identified with CD autoimmunity (CDA) and persistent tTGA positivity; of these children, 85 fulfilled CD criteria of biopsy-verified histopathology or persistently high tTGA levels. Cox regression, modeling gluten intake between ages 1 and 2 years (i.e., in 1-year-olds), and joint modeling of cumulative gluten intake throughout childhood were used t

SUBMITTER: Marild K 

PROVIDER: S-EPMC6684402 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature