Cutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection.

ABSTRACT: Differentiation of T follicular helper (T_FH) cells is regulated by a complex transcriptional network, with mutually antagonistic Bcl6-Blimp1 as a core regulatory axis. It is well established that Tcf1 acts upstream of Bcl6 for its optimal induction to program T_FH cell differentiation. In this study, we show that whereas genetic ablation of Tcf1 in mice greatly diminished T_FH cells in response to viral infection, compound deletion of Blimp1 with Tcf1 restored T_FH cell frequency, numbers, and generation of germinal center B cells. Aberrant upregulation of T-bet and Id2 in Tcf1-deficient T_FH cells was also largely rectified by ablating Blimp1. Tcf1 chromatin immunoprecipitation sequencing in T_FH cells identified two strong Tcf1

SUBMITTER: Shao P 

PROVIDER: S-EPMC6684471 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature