The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location.

ABSTRACT: Recent studies have characterized populations of memory CD8+ T cells that do not recirculate through the blood but are, instead, retained in nonlymphoid tissues. Such CD8+ tissue resident memory T cells (TRM) are critical for pathogen control at barrier sites. Identifying TRM and defining the basis for their tissue residency is therefore of considerable importance for understanding protective immunity and improved vaccine design. Expression of the molecule CD69 is widely used as a definitive marker for TRM, yet it is unclear whether CD69 is universally required for producing or retaining TRM Using multiple mouse models of acute immunization, we found that the functional requirement for CD69 was highly variable, depending on the tissue examined, playing no detectable role in generation of T

SUBMITTER: Walsh DA 

PROVIDER: S-EPMC6684481 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature