Dual-active antifungal agents containing strobilurin and SDHI-based pharmacophores.

ABSTRACT: Crop disease management often implies repeated application of fungicides. However, the increasing emergence of fungicide-resistant pathogens requires their rotation or combined use. Tank-mix combinations using fungicides with different modes of action are often hard to manage by farmers. An alternative and unexploited strategy are bifunctional fungicides, i.e. compounds resulting from conjugation of the pharmacophores of fungicides with different mechanisms of action. In this paper we describe a new approach to antifungal treatments based on the synthesis of dual agents, obtained by merging the strobilurin and succinate dehydrogenase inhibitor pharmacophores into a new entity. The compounds were tested against important fungal plant pathogens and showed good inhibition of Pyricularia oryza

SUBMITTER: Zuccolo M 

PROVIDER: S-EPMC6684525 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature