Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study.

ABSTRACT: Metabolomics is an emerging science that can inform pathogenic mechanisms behind clinical phenotypes in COPD. We aimed to understand disturbances in the serum metabolome associated with respiratory outcomes in ever-smokers from the SPIROMICS cohort. We measured 27 serum metabolites, mostly amino acids, by ¹H-nuclear magnetic resonance spectroscopy in 157 white ever-smokers with and without COPD. We tested the association between log-transformed metabolite concentrations and one-year incidence of respiratory exacerbations after adjusting for age, sex, current smoking, body mass index, diabetes, inhaled or oral corticosteroid use, study site and clinical predictors of exacerbations, including FEV₁% predicted and history of exacerbations. The mean age of participants was

SUBMITTER: Labaki WW 

PROVIDER: S-EPMC6684630 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature