Transcriptomic analysis of insecticide resistance in the lymphatic filariasis vector Culex quinquefasciatus.

ABSTRACT: Culex quinquefasciatus plays an important role in transmission of vector-borne diseases of public health importance, including lymphatic filariasis (LF), as well as many arboviral diseases. Currently, efforts to tackle C. quinquefasciatus vectored diseases are based on either mass drug administration (MDA) for LF, or insecticide-based interventions. Widespread and intensive insecticide usage has resulted in increased resistance in mosquito vectors, including C. quinquefasciatus. Herein, the transcriptome profile of Ugandan bendiocarb-resistant C. quinquefasciatus was explored to identify candidate genes associated with insecticide resistance. High levels of insecticide resistance were observed for five out of six insecticides tested, with the lowest mortality (0.97%) reported to permethrin

SUBMITTER: Silva Martins WF 

PROVIDER: S-EPMC6684662 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature