Personalized Epigenome Remodeling Under Biochemical and Psychological Changes During Long-Term Isolation Environment.

ABSTRACT: It has been reported that several aspects of human health could be disturbed during a long-term isolated environment (for instance, the Mars-500 mission), including psychiatric disorders, circadian disruption, temporal dynamics of gut microbiota, immune responses, and physical-activity-related neuromuscular performance. Nevertheless, the mechanisms underlying these disturbances and the interactions among different aspects of human adaptation to extreme environments remain to be elucidated. Epigenetic features, like DNA methylation, might be a linking mechanism that explains the involvement of environmental factors between the human genome and the outcome of health. We conducted an exploration of personalized longitudinal DNA methylation patterns of the peripheral whole blood cells, profili

SUBMITTER: Liang F 

PROVIDER: S-EPMC6684777 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature