Changes in Ca²⁺ Removal Can Mask the Effects of Geometry During IP₃R Mediated Ca²⁺ Signals.

ABSTRACT: Calcium (Ca²⁺) signals are ubiquitous. Most intracellular Ca²⁺ signals involve the release of Ca²⁺ from the endoplasmic reticulum (ER) through Inositol 1,4,5-Trisphosphate Receptors (IP₃Rs). The non-uniform spatial organization of IP₃Rs and the fact that their individual openings are coupled via cytosolic Ca²⁺ are key factors for the variety of spatio-temporal distributions of the cytosolic [Ca²⁺] and the versatility of the signals. In this paper we combine experiments performed in untreated and in progesterone-treated Xenopus laevis oocytes and mathematical models to investigate how the interplay between geometry (the IP₃R spatial distribution) and dynamics (the processes th

SUBMITTER: Piegari E 

PROVIDER: S-EPMC6684793 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature