Strength of resting state functional connectivity and local GABA concentrations predict oral reading of real and pseudo-words.

ABSTRACT: Reading is a learned activity that engages multiple cognitive systems. In a cohort of typical and struggling adult readers we show evidence that successful oral reading of real words is related to gamma-amino-butyric acid (GABA) concentration in the higher-order language system, whereas reading of unfamiliar pseudo-words is not related to GABA in this system. We also demonstrate the capability of resting state functional connectivity (rsFC) combined with GABA measures to predict single real word compared to pseudo-word reading performance. Results show that the strength of rsFC between left fusiform gyrus (L-FG) and higher-order language systems predicts oral reading behavior of real words, irrespective of the local concentration of GABA. On the other hand, pseudo-words, which require grap

SUBMITTER: Krishnamurthy LC 

PROVIDER: S-EPMC6684813 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature