Delivery of the <i>Pseudomonas aeruginosa</i> Phospholipase Effectors PldA and PldB in a VgrG- and H2-T6SS-Dependent Manner.

ABSTRACT: The bacterial pathogen Pseudomonas aeruginosa uses three type VI secretion systems (T6SSs) to drive a multitude of effector proteins into eukaryotic or prokaryotic target cells. The T6SS is a supramolecular nanomachine, involving a set of 13 core proteins, which resembles the contractile tail of bacteriophages and whose tip is considered as a puncturing device helping to cross membranes. Effectors can attach directly to the T6SS spike which is composed of a VgrG (valine-glycine-rich proteins) trimer, of which P. aeruginosa produces several. We have previously shown that the master regulator RsmA controls the expression of all three T6SS gene clusters (H1-, H2- and H3-T6SS) and a range of remote vgrG and effector genes. We also demonstrated that specific interactions be

SUBMITTER: Wettstadt S 

PROVIDER: S-EPMC6684961 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature