Serological inference of past primary and secondary dengue infection: implications for vaccination.

ABSTRACT: Owing to the finding that Dengvaxia^® (the only licensed dengue vaccine to date) increases the risk of severe illness among seronegative recipients, the World Health Organization has recommended screening individuals for their serostatus prior to vaccination. To decide whether and how to carry out screening, it is necessary to estimate the transmission intensity of dengue and to understand the performance of the screening method. In this study, we inferred the annual force of infection (FOI; a measurement of transmission intensity) of dengue virus in three locations in Vietnam: An Giang (FOI = 0.04 for the below 10 years age group and FOI = 0.20 for the above 10 years age group), Ho Chi Minh City (FOI = 0.12) and Quang Ngai (FOI = 0.05). In addition, we show that using a quantita

SUBMITTER: Lam HM 

PROVIDER: S-EPMC6685028 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature