An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma.

ABSTRACT: Medulloblastoma (MB) is a pediatric tumor of the cerebellum divided into four groups. Group 3 is of bad prognosis and remains poorly characterized. While the current treatment involving surgery, radiotherapy, and chemotherapy often fails, no alternative therapy is yet available. Few recurrent genomic alterations that can be therapeutically targeted have been identified. Amplifications of receptors of the TGFβ/Activin pathway occur at very low frequency in Group 3 MB. However, neither their functional relevance nor activation of the downstream signaling pathway has been studied. We showed that this pathway is activated in Group 3 MB with some samples showing a very strong activation. Beside genetic alterations, we demonstrated that an ActivinB autocrine stimulation is responsible for pathwa

SUBMITTER: Morabito M 

PROVIDER: S-EPMC6685082 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature