Gut Bacterial Metabolite Urolithin A (UA) Mitigates Ca²⁺ Entry in T Cells by Regulating miR-10a-5p.

ABSTRACT: The gut microbiota influences several biological functions including immune responses. Inflammatory bowel disease is favorably influenced by consumption of several dietary natural plant products such as pomegranate, walnuts, and berries containing polyphenolic compounds such as ellagitannins and ellagic acid. The gut microbiota metabolizes ellagic acid resulting in the formation of bioactive urolithins A, B, C, and D. Urolithin A (UA) is the most active and effective gut metabolite and acts as a potent anti-inflammatory and anti-oxidant agent. However, whether gut metabolite UA affects the function of immune cells remains incompletely understood. T cell proliferation is stimulated by store operated Ca²⁺ entry (SOCE) resulting from stimulation of Orai1 by STIM1/STIM2. We show her

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6685097 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature