A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae.

ABSTRACT:

Background

Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular carcinoma (HCC) and the underlying mechanisms of action remain to be fully elucidated.

Methods

In this study, we aimed to elucidate the underlying molecular mechanisms of RSM in the treatment of HCC using a network pharmacology approach. In vivo and in vitro experiments were also performed to validate the therapeutic effects of RSM on HCC.

Results

In total, 62 active compounds from RSM and 72 HCC-related targets were identified through network pharmacological analysis. RSM was found to play a critical role in HCC via multiple targets and pathways,

SUBMITTER: Luo Y 

PROVIDER: S-EPMC6685170 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature