Development of a Zebrafish S1500+ Sentinel Gene Set for High-Throughput Transcriptomics.

ABSTRACT: Sentinel gene sets have been developed with the purpose of maximizing the information from targeted transcriptomic platforms. We recently described the development of an S1500+ sentinel gene set, which was built for the human transcriptome, utilizing a data- and knowledge-driven hybrid approach to select a small subset of genes that optimally capture transcriptional diversity, correlation with other genes based on large-scale expression profiling, and known pathway annotation within the human genome. While this detailed bioinformatics approach for gene selection can in principle be applied to other species, the reliability of the resulting gene set depends on availability of a large body of transcriptomics data. For the model organism zebrafish, we aimed to create a similar sentinel gene s

SUBMITTER: Balik-Meisner MR 

PROVIDER: S-EPMC6685209 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature