Gelatin-based perfusable, endothelial carotid artery model for the study of atherosclerosis.

ABSTRACT:

Background

Carotid artery geometry is important for recapitulating a pathophysiological microenvironment to study wall shear stress (WSS)-induced endothelial dysfunction in atherosclerosis. Endothelial cells (ECs) cultured with hydrogel have been shown to exhibit in vivo-like behaviours. However, to date, studies using hydrogel culture have not fully recapitulated the 3D geometry and blood flow patterns of real-life healthy or diseased carotid arteries. In this study, we developed a gelatin-patterned, endothelialized carotid artery model to study the endothelium response to WSS.

Results

Two representative regions were selected based on the computational fluid dynamics on the TF-shaped carotid artery: Region ECA (external carotid artery) and Region CS (carotid sinus). Progres

SUBMITTER: Chen R 

PROVIDER: S-EPMC6685230 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature