Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer.

ABSTRACT:

Background

Noninvasive and effective methods of early diagnosis of colorectal cancer (CRC) are underexplored. Inflammation is known to play an important role in the tumor microenvironment of CRC. Therefore, the aim of this study was to elucidate novel inflammatory biomarkers related to early diagnosis and prognosis of CRC.

Methods

Based on the results from a multiplex assay and a pan-cancer screening of TCGA data with 18 cancer types, we identified several targeted biomarkers. We further confirmed these results using a trial cohort of 112 CRC patients and 151 controls (59 healthy donors, 52 colitis and 40 colorectal adenoma patients) by Elisa and immunohistochemistry (IHC). The biomarkers expression levels in CRC patients of different clinical stages were compared. The targe

SUBMITTER: Wang D 

PROVIDER: S-EPMC6685266 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature