The use of chicken and insect infection models to assess the virulence of African Salmonella Typhimurium ST313.

ABSTRACT: Over recent decades, Salmonella infection research has predominantly relied on murine infection models. However, in many cases the infection phenotypes of Salmonella pathovars in mice do not recapitulate human disease. For example, Salmonella Typhimurium ST313 is associated with enhanced invasive infection of immunocompromised people in Africa, but infection of mice and other animal models with ST313 have not consistently reproduced this invasive phenotype. The introduction of alternative infection models could help to improve the quality and reproducibility of pathogenesis research by facilitating larger-scale experiments. To investigate the virulence of S. Typhimurium ST313 in comparison with ST19, a combination of avian and insect disease models were used. We performed experimental infe

SUBMITTER: Lacharme-Lora L 

PROVIDER: S-EPMC6685681 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature