User-Centered Development of an Online Platform for Drug Dosing Recommendations in Pediatrics.
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ABSTRACT: Background
Drug therapy in pediatric patients is a complex process. Children are subject to continuous growth and variation in drug-metabolizing enzyme activity, requiring continuous adaption of dosages. In Germany, currently no publicly available database exists that provides evidence-based information on drug dosages in pediatrics. For local drug dosing support, a prototype database has been developed within the Children's Hospital, Erlangen. A user-centered development process was initiated to establish an online platform for evidence-based dosing recommendations, as well as pharmacological and pharmaceutical drug information in pediatrics.Objectives
The objectives of the study were to survey the demand for such a platform and to assess the usability of the different versions of the developed system.Methods
The developed prototype was evaluated in a pluralistic walkthrough with prospective end users. After a redesign, the second prototype of the online platform underwent an online usability testing based on a tailored questionnaire and the System Usability Scale (SUS) (n = 12).Results
Eleven of 12 participants expressed a demand for an online platform for pediatric dosing recommendations. The majority of the participants requested the integration of extended features, such as drug-drug interaction alerts, or information on adverse effects, pharmacokinetics, and pharmacodynamics. Particularly noteworthy is the demand for an online calculator; 5 of a total of 15 participants explicitly requested a calculator for dosages (based on age, weight, body surface) and glomerular filtration rate. The usability of the second prototype was rated "good to excellent" with a median SUS of 81.25.Conclusion
Local domain experts demand an online platform for pediatric dosing recommendations. The application of the user-centered design approach enabled the development of a prototype suitable for practical use. Multiple additional required functionalities have been identified, whereby the importance of an online calculator for patient-individual dosing recommendations was particularly emphasized.
SUBMITTER: Rodle W
PROVIDER: S-EPMC6685729 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Publications
User-Centered Development of an Online Platform for Drug Dosing Recommendations in Pediatrics.
Rödle Wolfgang W Wimmer Stefan S Zahn Julia J Prokosch Hans-Ulrich HU Hinkes Bernward B Neubert Antje A Rascher Wolfgang W Kraus Stefan S Toddenroth Dennis D Sedlmayr Brita B
Applied clinical informatics 20190807 4
<h4>Background</h4>Drug therapy in pediatric patients is a complex process. Children are subject to continuous growth and variation in drug-metabolizing enzyme activity, requiring continuous adaption of dosages. In Germany, currently no publicly available database exists that provides evidence-based information on drug dosages in pediatrics. For local drug dosing support, a prototype database has been developed within the Children's Hospital, Erlangen. A user-centered development process was ini ...[more]
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