N-acetylcysteine yields sex-specific efficacy for cue-induced reinstatement of nicotine seeking.

ABSTRACT: Women report greater craving during certain phases of the menstrual cycle. As well, research indicates that pharmacotherapies for smoking may be less efficacious in women compared with men, which may be due to interactions with natural fluctuations in ovarian hormone levels. N-Acetylcysteine (NAC) is a glutamatergic compound that has shown some efficacy in treating substance use disorders and aids in the prevention of relapse. However, it is unclear whether NAC has sex-specific effectiveness for nicotine relapse treatment. Given that NAC has shown promise to reduce nicotine reinstatement in preclinical models using male rats, the exploration of potential sex differences in the efficacy of NAC is warranted. Using a rat model, we first investigated the ability of NAC treatment (100 mg/kg, ip

SUBMITTER: Goenaga J 

PROVIDER: S-EPMC6685767 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature