The spectrum of spinal cord lesions in a primate model of multiple sclerosis.

ABSTRACT:

Background

Experimental autoimmune encephalomyelitis (EAE) in the common marmoset is a nonhuman primate model of multiple sclerosis (MS) that shares numerous clinical, radiological, and pathological features with MS. Among the clinical features are motor and sensory deficits that are highly suggestive of spinal cord (SC) damage.

Objective

To characterize the extent and nature of SC damage in symptomatic marmosets with EAE using a combined magnetic resonance imaging (MRI) and histopathology approach.

Materials and methods

SC tissues from five animals were scanned using 7 T MRI to collect high-resolution ex vivo images. Lesions were segmented and classified based on shape, size, and distribution along the SC. Tissues were processed for histopathological characterization

SUBMITTER: Lefeuvre JA 

PROVIDER: S-EPMC6685769 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature