Zinc-α2-glycoprotein as an inhibitor of amine oxidase copper-containing 3.

ABSTRACT: Zinc-α2-glycoprotein (ZAG) is a major plasma protein whose levels increase in chronic energy-demanding diseases and thus serves as an important clinical biomarker in the diagnosis and prognosis of the development of cachexia. Current knowledge suggests that ZAG mediates progressive weight loss through β-adrenergic signalling in adipocytes, resulting in the activation of lipolysis and fat mobilization. Here, through cross-linking experiments, amine oxidase copper-containing 3 (AOC3) is identified as a novel ZAG binding partner. AOC3-also known as vascular adhesion protein 1 (VAP-1) and semicarbazide sensitive amine oxidase (SSAO)-deaminates primary amines, thereby generating the corresponding aldehyde, H₂O₂ and NH₃. It is an ectoenzyme largely expressed by a

SUBMITTER: Romauch M 

PROVIDER: S-EPMC6685929 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature