Characterization of cellular transcriptomic signatures induced by different respiratory viruses in human reconstituted airway epithelia.

ABSTRACT: Acute respiratory infections, a large part being of viral origin, constitute a major public health issue. To propose alternative and/or new therapeutic approaches, it is necessary to increase our knowledge about the interactions between respiratory viruses and their primary cellular targets using the most biologically relevant experimental models. In this study, we used RNAseq to characterize and compare the transcriptomic signature of infection induced by different major respiratory viruses (Influenza viruses, hRSV and hMPV) in a model of reconstituted human airway epithelia. Our results confirm the importance of several cellular pathways commonly or specifically induced by these respiratory viruses, such as the innate immune response or antiviral defense. A very interesting common featur

SUBMITTER: Nicolas de Lamballerie C 

PROVIDER: S-EPMC6685967 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature