Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types.

ABSTRACT: Non-oncogene addiction (NOA) genes are essential for supporting the stress-burdened phenotype of tumours and thus vital for their survival. Although NOA genes are acknowledged to be potential drug targets, there has been no large-scale attempt to identify and characterise them as a group across cancer types. Here we provide the first method for the identification of conditional NOA genes and their rewired neighbours using a systems approach. Using copy number data and expression profiles from The Cancer Genome Atlas (TCGA) we performed comparative analyses between high and low genomic stress tumours for 15 cancer types. We identified 101 condition-specific differential coexpression modules, mapped to a high-confidence human interactome, comprising 133 candidate NOA rewiring hub genes. We o

SUBMITTER: Hjaltelin JX 

PROVIDER: S-EPMC6685999 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature