Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation.

ABSTRACT: Mammalian embryos change shape dramatically upon implantation. The cellular and molecular mechanism underlying this transition are largely unknown. Here, we show that this transition is directed by cross talk between the embryonic epiblast and the first extra-embryonic tissue, the trophectoderm. Specifically, we show via visualisation of a Cdx2-GFP reporter line and pharmacologically mediated loss and gain of function experiments that the epiblast provides FGF signal that results in differential fate acquisition in the multipotent trophectoderm leading to the formation of a tissue boundary within this tissue. The trophectoderm boundary becomes essential for expansion of the tissue into a multi-layered epithelium. Folding of this multi-layered trophectoderm induces spreading of the second e

SUBMITTER: Christodoulou N 

PROVIDER: S-EPMC6686005 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature