Annulus Fibrosus Repair Using High-Density Collagen Gel: An In Vivo Ovine Model.

ABSTRACT:

Study design

Ovine in vivo study.

Objective

To perform lateral approach lumbar surgery in an ovine model to administer an injectable riboflavin cross-linked high-density collagen (HDC) gel and to assess its ability to mitigate intervertebral disc (IVD) degeneration after induced annulus fibrosus (AF) injury.

Summary of background data

Biological-based injectable gels have shown efficacy in restoring biomechanical, radiographic, and histological parameters in IVD-injured animal models. Riboflavin cross-linked HDC gel has previously demonstrated retention of nucleus pulposus (NP) tissue, reduced loss of disc height, and prevention of terminal cellular degenerative changes in rat-tail spines. However, this biological therapy has never been tested in large animal models.<

SUBMITTER: Pennicooke B 

PROVIDER: S-EPMC6686199 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature