DNA Methylation Changes in Regional Lung Macrophages Are Associated with Metabolic Differences.

ABSTRACT: A number of pulmonary diseases occur with upper lobe predominance, including cystic fibrosis and smoking-related chronic obstructive pulmonary disease. In the healthy lung, several physiologic and metabolic factors exhibit disparity when comparing the upper lobe of the lung to lower lobe, including differences in oxygenation, ventilation, lymphatic flow, pH, and blood flow. In this study, we asked whether these regional differences in the lung are associated with DNA methylation changes in lung macrophages that could potentially lead to altered cell responsiveness upon subsequent environmental challenge. All analyses were performed using primary lung macrophages collected via bronchoalveolar lavage from healthy human subjects with normal pulmonary function. Epigenome-wide DNA methylation w

SUBMITTER: Armstrong DA 

PROVIDER: S-EPMC6686200 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature