LINC00309 is associated with short disease-free survival in breast cancer.

ABSTRACT:

Background

Long non-coding RNAs play an important role in breast cancer. Even with adjuvant hormone therapy, patients with estrogen receptor positive breast cancer can present with recurrences and distant metastases. We investigated whether the expression of a novel long non-coding RNA LINC00309 can predict the outcome of breast cancer, especially for hormone-receptor positive patients.

Methods

This retrospective study collected 290 breast cancer patients including 161 patients with hormone-positive. qPCR was performed to detect the expression of LINC00309. Kaplan-Meier and Cox risk proportion model were applied to disclose the function of LINC00309 for breast cancer prognosis.

Results

LINC00309 high expression was an independent predictor for worse disease-free survi

SUBMITTER: Huang S 

PROVIDER: S-EPMC6686222 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature