The analysis of virulence factors and antibiotic resistance between Helicobacter pylori strains isolated from gastric antrum and body.

ABSTRACT:

Background

Individuals can be infected with multiple strains of Helicobacter pylori. However, the differences among co-infecting strains have not been well analyzed yet. This study aimed to investigate whether the virulence factors and antibiotic resistance patterns of H. pylori differ between strains isolated from different locations of the stomach in the same patient.

Methods

H. pylori isolates were obtained from the antrum and body of the stomach. Genetic differences were examined by random amplified polymorphic DNA (RAPD) fingerprinting. Antibiotic resistance was assessed using the agar dilution method. Virulence factors were identified by polymerase chain reaction and DNA sequencing.

Results

Among 80 patients, co-infection by two H. pylori strains was detected in

SUBMITTER: Seo JW 

PROVIDER: S-EPMC6686454 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature