The synergistic antitumor effect of Huaier combined with 5-Florouracil in human cholangiocarcinoma cells.

ABSTRACT:

Background

5-Florouracil (5-FU) is a commonly used chemotherapeutic drug for cholangiocarcinoma, whereas it has unsatisfactory effect, and patients often have chemo-resistance to it. The combination of chemotherapeutic agents and traditional Chinese medicine has already exhibited a promising application in oncotherapy. Huaier extract (Huaier) has been used in clinical practice widely, exhibiting good anti-tumor effect. This paper aims to investigate the possibility of combination 5-FU and Huaier as a treatment for cholangiocarcinoma.

Methods

A series of experiments were performed on the Huh28 cells in vitro, which involved cell proliferation, colony formation, apoptosis, cell cycle, migratory and invasive tests. Besides, western blots were also performed to examine the poten

SUBMITTER: Fu Z 

PROVIDER: S-EPMC6686517 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature