Bioreactor System to Perfuse Mesentery Microvascular Networks and Study Flow Effects During Angiogenesis.

ABSTRACT:

Impact statement

Microvascular remodeling, or angiogenesis, plays a central role in multiple pathological conditions, including cancer, diabetes, and ischemia. Tissue-engineered in vitro models have emerged as tools to elucidate the mechanisms that drive the angiogenic process. However, a major challenge with model development is recapitulating the physiological complexity of real microvascular networks, including incorporation of the entire vascular tree and hemodynamics. This study establishes a bioreactor system that incorporates real microvascular networks with physiological flow as a novel ex vivo tissue culture model, thereby providing a platform to evaluate angiogenesis in a physiologically relevant environment.

SUBMITTER: Motherwell JM 

PROVIDER: S-EPMC6686705 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature