Risk factors for orofacial clefts in India: A case-control study.

ABSTRACT:

Background

Orofacial clefts (OFC) are linked with several genetic and environmental factors. The aim of this study was to explore the association of potential risk factors with OFCs in India.

Methods

This was a hospital-based, matched case-control (1:4 ratio; matching done for parity) study conducted in Hyderabad, Bengaluru, and Delhi-National Capital Region. Cases (nonsyndromic clefts) were recruited from treatment centers, while controls (live births) were recruited from maternity centers. Information on exposures was collected during personal interviews. Exposures of interest included folic acid supplementation during the peri-conceptional period, consanguineous marriage, exposure to drugs, infections during pregnancy, family history of OFC, and dietary factors.

Result

SUBMITTER: Neogi SB 

PROVIDER: S-EPMC6686724 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature