Resorbable plating system stabilizes tissue-engineered intervertebral discs implanted ex vivo in canine cervical spines.

ABSTRACT: Total disc replacement using tissue-engineered intervertebral discs (TE-IVDs) may offer a biological alternative to treat radiculopathy caused by disc degeneration. A composite TE-IVD was previously developed and evaluated in rat tail and beagle cervical spine models in vivo. Although cell viability and tissue integration into host tissue were promising, significant implant displacement occurred at multiple spinal levels. The goal of the present study was to assess the effects of a resorbable plating system on the stiffness of motion segments and stability of tissue-engineered implants subjected to axial compression. Canine motion segments from levels C2/C3 to C5/C6 were assessed as intact (CTRL), after discectomy (Dx), with an implanted TE-IVD only (PLATE-), and with a TE-IVD combined wit

SUBMITTER: Mojica-Santiago JA 

PROVIDER: S-EPMC6686817 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature