Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical.

ABSTRACT: Chronic back and neck pain is a prevalent disability, often caused by degeneration of the intervertebral disc. Because current treatments for this condition are less than satisfactory, a great deal of effort is being applied to develop new solutions, including regenerative strategies. However, the path from initial promising idea to clinical use is fraught with many hurdles to overcome. Many of the keys to success are not necessarily linked to science or innovation. Successful translation to clinic will also rely on planning and awareness of the hurdles. It will be essential to plan your entire path to clinic from the outset and to do this with a multidisciplinary team. Take advice early on regulatory aspects and focus on generating the proof required to satisfy regulatory approval. Scient

SUBMITTER: Thorpe AA 

PROVIDER: S-EPMC6686834 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature