Impact of digital video analytics on accuracy of chemobehavioural phenotyping in aquatic toxicology.

ABSTRACT: Chemobehavioural phenotypic analysis using small aquatic model organisms is becoming an important toolbox in aquatic ecotoxicology and neuroactive drug discovery. The analysis of the organisms' behavior is usually performed by combining digital video recording with animal tracking software. This software detects the organisms in the video frames, and reconstructs their movement trajectory using image processing algorithms. In this work we investigated the impact of video file characteristics, video optimization techniques and differences in animal tracking algorithms on the accuracy of quantitative neurobehavioural endpoints. We employed larval stages of a free-swimming euryhaline crustacean Artemia franciscana,commonly used for marine ecotoxicity testing, as a proxy modelto assess

SUBMITTER: Henry J 

PROVIDER: S-EPMC6686839 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature