Transcranial Optical Monitoring of Cerebral Hemodynamics in Acute Stroke Patients during Mechanical Thrombectomy.

ABSTRACT:

Introduction

Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular "snapshot." Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcranial monitoring of cerebral microvasculature.

Methods

Here, we use a combined DCS/DOS system to monitor frontal lobe hemodynamic changes during endovascular treatment of

SUBMITTER: Forti RM 

PROVIDER: S-EPMC6686873 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature