Coordinated Roles of the Putative Ceramide-Conjugation Protein, Cwh43, and a Mn²⁺-Transporting, P-Type ATPase, Pmr1, in Fission Yeast.

ABSTRACT: Genetically controlled mechanisms of cell division and quiescence are vital for responding to changes in the nutritional environment and for cell survival. Previously, we have characterized temperature-sensitive (ts) mutants of the cwh43 gene in fission yeast, Schizosaccharomyces pombe, which is required for both cell proliferation and nitrogen starvation-induced G0 quiescence. Cwh43 encodes an evolutionarily conserved transmembrane protein that localizes in endoplasmic reticulum (ER). Defects in this protein fail to divide in low glucose and lose mitotic competence under nitrogen starvation, and also affect lipid metabolism. Here, we identified mutations of the pmr1 gene, which encodes an evolutionarily conserved Ca²⁺/Mn²⁺-transporting P-type ATP

SUBMITTER: Nakazawa N 

PROVIDER: S-EPMC6686924 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature