Maternal Experience Leads to Lasting Gene Expression Changes in Some Regions of the Mouse Brain.

ABSTRACT: Rodent maternal behaviors are due to the coordinated effects of fluctuating hormones, with their onset triggered by interactions with newborn pups. Previous studies have shown that many genes have changes in expression during peripartum stages. However, it is unclear if there are long-lasting changes in gene expression, well after the performance of maternal behaviors, that could influence physiology and behavior throughout the remaining lifespan. Here, gene expression differences were examined in mouse between age-matched virgin and primiparous females, at least 4 weeks after weaning. Of the five brain regions examined-hypothalamus, hippocampus, cortex, cerebellum, and the amygdala-only the hypothalamus had thousands of genes with significant expression differences. The cerebellum had 130

SUBMITTER: Arbeitman MN 

PROVIDER: S-EPMC6686928 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature