Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis.

ABSTRACT:

Importance

Long-term immune sequelae after sepsis are poorly understood.

Objective

To assess whether abnormalities in the host immune response during hospitalization for sepsis persist after discharge.

Design, settings, and participants

This prospective, multicenter cohort study enrolled and followed up for 1 year adults who survived a hospitalization for sepsis from January 10, 2012, to May 25, 2017, at 12 US hospitals.

Exposures

Circulating levels of inflammation (interleukin 6 and high-sensitivity C-reactive protein [hs-CRP]), immunosuppression (soluble programmed death ligand 1 [sPD-L1]), hemostasis (plasminogen activator inhibitor 1 and D-dimer), endothelial dysfunction (E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1),

SUBMITTER: Yende S 

PROVIDER: S-EPMC6686981 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature